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Publications

2024
Atif Ahmed Siddiqui, Merquiol, Emmanuelle , Bruck-Haimson, Reut , Hirbawi, Joud , Boocholez, Hana , Cohen, Irit , Yan, Yonghong , Don, Meng Qiu, Blum, Galia , and Cohen, Ehud . 10/3/2024. “ Cathepsin B Promotes AΒ Proteotoxicity By Modulating Aging Regulating Mechanisms ”. Nature Communication. . Publisher's Version
Odelia Tepper-Shimshon, Tetro, Nino , Hamed, Roa’a , Erenburg, Natalia , Merquiol, Emmanuelle , Dey, Gourab , Haim, Agam , Dee, Tali , Duvdevani, Noa , Kevorkian, Talin , Blum, Galia , Yavin, Eylon , and Eyal, Sara . 9/14/2024. “Differential Effect Of Simulated Microgravity On The Cellular Uptake Of Small Molecules”. Pharmaceutics. . Publisher's Version
Gourab Dey, Sinai-Turyansky, Reut , Yakobovich, Evalyn , Merquiol, Emmanuelle , Loboda, Jure , Sridharan, Nikhila , Houri-Haddad, Yael , Polak, David , Yona, Simon , Turk, Dusan , Wald, Ori , and Blum, Galia . 7/5/2024. “Development And Application Of Reversible And Irreversible Covalent Probes For Human And Mouse Cathepsin-K Activity Detection, Revealing Nuclear Activity”. Advanced Science. . Publisher's Version
Preety Panwar, Olesen, Jacob Bastholm, Blum, Galia , Delaisse, Jean-Marie , Søe, Kent , and Brömme, Dieter . 3/28/2024. “ Real-Time Analysis Of Osteoclast Resorption And Fusion Dynamics In Response To Bone Resorption Inhibitors ”. Scientific Reports. . Publisher's Version
Roa’a Hamed, Merquiol, Emmanuelle , Zlotver, Ivan , Blum, Galia , Eyal, Sara , and Ekstein, Dana . 1/31/2024. “ Challenges In Batch-To-Bed Translation Involving Inflammation-Targeting Compounds In Chronic Epilepsy: The Case Of Cathepsin Activity-Based Probes ”. Acs Omega, 9, 6. . Publisher's Version
2022
Yonit Yitzhak, Gaikwad, Hanmant , Weiss-Sadan, Tommy , Merquiol, Emmanuelle , Turk, Boris , and Blum, Galia . 1/27/2022. “Improved Cathepsin Probes For Sensitive Molecular Imaging”. Molecules ., 27, (3), Pp. 842. . Publisher's Version
2021
Adi Jacob Berger, Gigi, Elinor , Kupershmidt, Lana , Meir, Zohar , Gavert, Nancy , Zwang, Yaara , Prior, Amir , Gilad, Shlomit , Harush, Uzi , Haviv, Izhak , Stemmer, Salomon M, Blum, Galia , Merquiol, Emmanuelle , Mardamshina, Mariya , Kaminski Strauss, Sivan , Friedlander, Gilgi , Bar, Jair , Kamer, Iris , Reizel, Yitzhak , Geiger, Tamar , Pilpel, Yitzhak , Levin, Yishai , Tanay, Amos , Barzel, Baruch , Reuveni, Hadas , and Straussman, Ravid . 10/21/2021. “Irs1 Phosphorylation Underlies The Non-Stochastic Probability Of Cancer Cells To Persist During Egfr Inhibition Therapy”. Nat Cancer ., 2, (10), Pp. 1055-1070. . Publisher's Version
Galia Blum, Verhelst, Steven H. L. , and Ma, Xiaowei . 9/9/2021. “Editorial: Development And Applications Of New Activity-Based Probes”. Front Chem. . Publisher's Version
Suresh Gangadevi, Badavath, Vishnu Nayak , Thakur, Abhishek , Yin, Na , Jonghe, Steven De , Acevedo, Orlando , Jochmans, Dirk , Leyssen, Pieter , Wang, Ke , Neyts, Johan , Yujie, Tao , and Blum, Galia . 2/25/2021. “Kobophenol A Inhibits Binding Of Host Ace2 Receptor With Spike Rbd Domain Of Sars-Cov-2, A Lead Compound For Blocking Covid-19”. J Phys Chem Lett. , 12, 7, Pp. 1793–1802. . Publisher's Version
Sai RK Meka, Younis, Tahsin , Reich, Eli , Elayyan, Jinan , Kumar, Ashok , Merquiol, Emmanuelle , Blum, Galia , Kalmus, Shira , Maatuf, Yonathan H. , Batshon, George , Nussbaum, Gabriel , Houri-Haddad, Yael , and Dvir-Ginzberg, Mona . 2/9/2021. “Tnfα Expression By Porphyromonas Gingivalis-Stimulated Macrophages Relies On Sirt1 Cleavage”. J Periodontal Res ., 56, (3), Pp. 535-546. . Publisher's Version
2020
Vishnu Nayak Badavath, Kumar, Akhil , Samanta, Pralok K, Maji, Siddhartha , Das, Anik , Blum, Galia , Jha, Anjali , and Sen, Anik . 11/17/2020. “Determination Of Potential Inhibitors Based On Isatin Derivatives Against Sars-Cov-2 Main Protease (M Pro): A Molecular Docking, Molecular Dynamics And Structure-Activity Relationship Studies”. J Biomol Struct Dyn, Pp. 1-19. . Publisher's Version
Diana Oelschlaegel, Sadan, Tommy Weiss , Salpeter, Seth , Krug, Sebastian , Blum, Galia , Schmitz, Werner , Schulze, Almut , and Michl, Patrick . 9/10/2020. “Cathepsin Inhibition Modulates Metabolism And Polarization Of Tumor-Associated Macrophages”. Cancers (Basel) , 12, 9, Pp. 2579. . Publisher's Version
2019
Tommy Weiss-Sadan, Ben-Nun, Yael , Maimoun, David , Merquiol, Emmanuelle , Abd-Elrahman, Ihab , Gotsman, Israel , and Blum, Galia . 8/12/2019. “A Theranostic Cathepsin Activity-Based Probe For Noninvasive Intervention In Cardiovascular Diseases”. Theranostics, 9, 20, Pp. 5731-5738. . Publisher's Version
Tommy Weiss Sadan, Itzhak, Gal , Kaschani, Farnusch , Yu, Zhanru , Mahameed, Mohamed , Anaki, Adi , Ben-Nun, Yael , Merquiol, Emmanuelle , Tirosh, Boaz , Kessler, Benedikt , Kaiser, Markus , and Blum, Galia . 4/22/2019. “Cathepsin L Regulates Metabolic Networks Controlling Rapid Cell Growth And Proliferation”. Molecular & Cellular Proteomics . . Publisher's Version
Weiss-Sadan T, D, Maimoun , D, Oelschlagel , F, Kaschani , D, Misiak , H, Gaikwad , Y, Ben-Nun , E, Merquiol , A, Anaki , D, Tsvirkun , M, Kaiser , P, Michl , I, Gotsman , and G, Blum . 2019. “Cathepsins Drive Anti-Inflammatory Activity By Regulating Autophagy And Mitochondrial Dynamics In Macrophage Foam Cells”. Cell Physiol Biochem., 53, 3, Pp. 550-572. . Publisher's Version
2018
Darya Tsvirkun, Ben-Nun, Yael , Merquiol, Emmanuelle , Zlotver, Ivan , Meir, Karen , Weiss-Sadan, Tommy , Matok, Ilan , Popovtzer, Rachela , and Blum, Galia . 9/26/2018. “Ct Imaging Of Enzymatic Activity In Cancer Using Covalent Probes Reveal A Size-Dependent Pattern.”. J Am Chem Soc., 140, 38, Pp. 12010–12020. . Publisher's Version
Meena NK, SP, Pattanayak , Y, Ben-Nun , S, Benhamron , S, Kumar , E, Merquiol , N, Hövelmeyer , G, Blum , and B, Tirosh . 8/24/2018. “Mtorc1 Activation In B Cells Confers Impairment Of Marginal Zone Microarchitecture By Exaggerating Cathepsin Activit”. Immunology., 155, 4, Pp. 505-518. . Publisher's Version
Rachel Blau, Epshtein, Yana , Pisarevsky, Evgeni , Tiram, Galia , Dangoor, Sahar Israeli , Yeini, Eilam , Krivitsky, Adva , Eldar-Boock, Anat , Ben-Shushan, Dikla , Gibori, Hadas , Scomparin, Anna , Green, Ori , Ben-Nun, Yael , Merquiol, Emmanuelle , Doron, Hila , Blum, Galia , Erez, Neta , Grossman, Rachel , Ram, Zvi , Shabat, Doron , and Satchi-Fainaro, Ronit . 5/24/2018. “Image-Guided Surgery Using Near-Infrared Turn-On Fluorescent Nanoprobes For Precise Detection Of Tumor Margins”. Theranostics., 8, 13, Pp. 3437–3460. . Publisher's Version
Gaikwad HK, D, Tsvirkun , Y, Ben-Nun , E, Merquiol , R, Popovtzer , and G, Blum . 3/14/2018. “Molecular Imaging Of Cancer Using X-Ray Computed Tomography With Protease Targeted Iodinated Activity-Based Probes”. Nano Lett., 18, 3, Pp. 1582-1591. . Publisher's Version
Gibori H, S, Eliyahu , A, Krivitsky , D, Ben-Shushan , Y, Epshtein , G, Tiram , R, Blau , P, Ofek , JS, Lee , E, Ruppin , L, Landsman , I, Barshack , T, Golan , E, Merquiol , G, Blum , and R, Satchi-Fainaro . 1/2/2018. “Amphiphilic Nanocarrier-Induced Modulation Of Plk1 And Mir-34A Leads To Improved Therapeutic Response In Pancreatic Cancer”. Nat Commun., 9, 1. . Publisher's Version